(R)-2-HG - a-KG-dependent dioxygenases inhibitor. CAS# 103404-90-6 60225 Bromosporine shows moderate cytotoxicity in

Bromosporine shows moderate cytotoxicity in HeLa cells at 18 µM

InChi: InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17

Molecular Weight: 352

32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4

CAS Number: 404951-53-7

(R)-2-HG - a-KG-dependent dioxygenases inhibitor. CAS# 103404-90-6 60225 Bromosporine shows moderate cytotoxicity inMutations, CAS No. 103404 90 6, in IDH1 and IDH2, the genes coding for isocitrate dehydrogenases 1 and 2, are common in several human cancers, such as leukemia and glioma, and result in overproduction of the (R) enantiomer of 2 hydroxyglutarate [(R) 2 HG]. Elucidation of the role of IDH mutations and (R) 2 HG in leukemogenesis has been hampered by a lack of appropriate cell based models. It has been recently reported that a canonical IDH1 mutant, IDH1