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6-dimethylpyrimidin-2-yl)benzene-1-sulfonamide
WZ4002 has a basic chemical framework (covalent pyrimidine) which is different from that of other EGFR inhibitors
InChiKey: KXGCNMMJRFDFNR-WDRJZQOASA-N
WEHI-539 HCl (WEHI-539 hydrochloride) has high affinity (IC50=1
PubMed PMID: 22485156
Chidamide Catalog No.:M9837-10 6-dimethylpyrimidin-2-yl)benzene-1-sulfonamideTucidinostat (also known as HBI 8000, Chidamide, and CS 055) is a benzamide type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10, with potential antineoplastic activity. Tucidinostat selectively binds to and inhibits HDAC leading to an increase of acetylation levels of histone protein H3. This agent also inhibits the expression of signaling kinases in the PI3K Akt and MAPK Ras signaling pathways and may result in cell cycle arrest