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CAS Number: 1450655-76-1
a Small Molecule Inhibitor Selective for Mutant JAK2 Kinase
S crizotinib
resulting in a defect in the cell’s antioxidative defenses and ultimately leading to an iron-dependent
InChiKey: MLRAMCAHIWHWRM-UHFFFAOYSA-N
I-BET762 (GSK525762) - BET Inhibitor. CAS# 1260907-17-2 Catalog No.:M60154-10S CAS Number: 1450655-76-1I BET762 (GSK525762), CAS No. 1260907 17 2, is a novel, highly potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 with an IC50 of ~35 nM. It suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation. It is highly selective over other bromodomain containing proteins. In vivo studies using I BET762 have demonstrated efficacy in a range of oncology and