IM-12 - CAS# 1129669-05-1 Size:Solid 10 mg PubMed PMID: 22366308

PubMed PMID: 22366308

100(13):7971-6

50 nM) in rat striatal membranes over A1R and A3R (Ki=1815 and >10000

34(5):2095-104

Chemical Name: 3-(4-((4-fluoro-4'-methyl-[1

IM-12 - CAS# 1129669-05-1 Size:Solid 10 mg PubMed PMID: 22366308IM 12 is a cell permeable indolylmaleimide that acts as a GSK 3 inhibitor. IM 12 is potent and selective enhances canonical Wnt signalling. IM 12 inhibits GSK 3 activity and subsequently increases catenin concentration significantly in hNPCs. When used to treat human neural progenitor cells, IM 12 promoted neuronal differentiation resulting in an increase of neuronal cells. Product information CAS Number: 1129669 05 1 Molecular Weight: 377. 41