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Perifosine (10 μM) completely inhibits the phosphorylation of Akt in MM
InChiKey: QMGUOJYZJKLOLH-UHFFFAOYSA-N
Smiles: C[C@@H](OC1=CC=C(C=C1C(=O)N1CCN(CC1)C1=NC=C(C=C1F)C(F)(F)F)S(C)(=O)=O)C(F)(F)F
is a potent and selective Pyruvate kinase M2 (PKM2) activator with EC50 ~92 nM
J Nucl Med
A 438079 Hydrochloride - CAS# 899431-18-6 Size:Solid 10 mg Perifosine (10 μM) completely inhibitsA 438079 is a P2X7 receptor antagonist. A438079 protects against acetaminophen induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation. A 438079 partially but significantly prevented the 6 OHDA induced depletion of striatal DA stores. P2X7R inhibitor A 438079 reduced electrographic and clinical seizure severity during status epilepticus and reduced seizure induced neuronal death in the neocortex. Blockade of P2X(7) receptors