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MP-470 (20 mg/kg) combined with Erlotinib significantly induces tumor growth inhibition (TGI)
CAS Number: 2204290-85-5
InChi: InChI=1S/C12H6Cl2O2/c13-7-1-3-11(14)9(5-7)10-6-8(15)2-4-12(10)16/h1-6H
A first-in-Asian phase 1 study to evaluate safety
InChi: InChI=1S/C22H22N6O/c1-13-9-20(29)25-18-6-4-5-16(22(18)24-13)14-7-8-19-17(10-14)21(26-28(19)3)15-11-23-27(2)12-15/h4-8
Thalidomide-5-PEG3-NH2 239T7519 Hydrochloride MP-470 (20 mg/kg) combined withThalidomide 5 PEG3 NH2 is a synthesized E3 ligase ligand linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Product information Molecular Weight: 405. 40 Formula: C19H23N3O7 Chemical Name: 5 {2 [2 (2 aminoethoxy)ethoxy]ethoxy} 2 (2, 6 dioxopiperidin 3 yl) 2, 3 dihydro 1H isoindole 1, 3 dione Smiles: NCCOCCOCCOC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O InChiKey: XMTFEXSNGIBNRG UHFFFAOYSA N
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