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AZ3146 is a novel and potent Mps1 inhibitor
InChi: InChI=1S/C6H8O4
InChiKey: XCFLWTZSJYBCPF-UHFFFAOYSA-N
21(3):234-40
Solubility: DMSO: 53 mg/mL(201
MS31 trihydrochloride tenol sodium AZ3146 is a novel andMS31 trihydrochloride is a potent, highly affinity and selective fragment like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 trihydrochloride potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 trihydrochloride selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 trihydrochloride potently inhibits binding of trimethyllysine containing peptides to SPIN1, and is not toxic to
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