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Picroside II protects against sepsis via suppressing inflammation in mice
PMCID: PMC6973588
MDA-MB-453 and MDA-MB-231 cell lines with an IC50 close to 100 μM
also known as Cy1001
277(1):114-20
Picroside II xamethonium Bromide Picroside II protects against sepsisPicroside II, an iridoid compound extracted from Picrorhiza, exhibits anti inflammatory and anti apoptotic activities. picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and NF B pathways. Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood brain barrier (BBB) after cerebral ischemia
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