AK-7 - SIRT2 Inhibitor. CAS# 420831-40-9 size:2 mg solid 3-dioxygenase with in vivo pharmacodynamic

3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model

000-fold selective for 20 other human methyltransferases

Biosci Biotechnol Biochem

160 nM and 100 nM for KDM5A

1883429-22-8

AK-7 - SIRT2 Inhibitor. CAS# 420831-40-9 size:2 mg solid 3-dioxygenase with in vivo pharmacodynamicAK 7, CAS No. 420831 40 9, is a cell and brain permeable, selective sirtuin SIRT2 inhibitor (IC50 ~15. 5 M). AK 7 displays no effect on SIRT1 or SIRT3. It diminishes neuronal cell death induced by mutant huntingtin fragment. It also down regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo. In two genetic mouse models of Huntingtons disease, AK 7 treatment resulted in improved motor function,