Syk-IN-1 7749944 InChi: InChI=1S/C23H26O10/c1-28-14-6-5-11-13-9-30-15-7-10(3-4-12(15)20(13)33-21(11)22(14)29-2)31-23-19(27)18(26)17(25)16(8-24)32-23/h3-7

InChi: InChI=1S/C23H26O10/c1-28-14-6-5-11-13-9-30-15-7-10(3-4-12(15)20(13)33-21(11)22(14)29-2)31-23-19(27)18(26)17(25)16(8-24)32-23/h3-7

HSP70 regulates Eg5 distribution within the mitotic spindle and modulates the cytotoxicity of Eg5 inhibitors

interference of MITF with ML-329 will be useful in characterizing the specific roles of MITF in melanoma and validate blockade of MITF function as a potential treatment of melanoma

no differences in latent time are observed

InChi: InChI=1S/C13H12N4S/c1-8(2)7-18-13-15-12-11(16-17-13)9-5-3-4-6-10(9)14-12/h3-6H

Syk-IN-1 7749944 InChi: InChI=1S/C23H26O10/c1-28-14-6-5-11-13-9-30-15-7-10(3-4-12(15)20(13)33-21(11)22(14)29-2)31-23-19(27)18(26)17(25)16(8-24)32-23/h3-7Syk IN 1 (compound 4) is a potent Syk inhibitor, with an IC50 of 35 nM. Product information CAS Number: 1491150 77 6 Molecular Weight: 366. 42 Formula: C18H22N8O Chemical Name: 3 {[(1R,2S) 2 aminocyclohexyl]amino} 5 [(1H indol 7 yl)amino] 1,2,4 triazine 6 carboxamide Smiles: NC(=O)C1=NN=C(N[C@@H]2CCCC[C@@H]2N)N=C1NC1=CC=CC2C=CNC=21 InChiKey: FPQNRXITKTZFMF NWDGAFQWSA N InChi: InChI=1S C18H22N8O c19 11 5 1 2 6 12(11)23 18 24 17(15(16(20)27)25 26 18)22